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Báo cáo y học: "Lithium alters brain activation in bipolar disorder in a task- and state-dependent manner: an fMRI study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Lithium alters brain activation in bipolar disorder in a task- and state-dependent manner: an fMRI study. | Annals of General Psychiatry BioMed Central Primary research Open Access Lithium alters brain activation in bipolar disorder in a task- and state-dependent manner an fMRI study Peter H Silverstone 1 Emily C Bell1 Morgan C Willson2 Sanjay Dave1 and Alan H Wilman2 Address Department of Psychiatry Faculty of Medicine University of Alberta 1E1.07 MacKenzie Center 8440-112 Street Edmonton Alberta T6G 2B7 Canada and 2Department of Biomedical Engineering Faculty of Medicine University of Alberta 1071 Research Transition Facility 8308114 Street Edmonton Alberta T6G 2V2 Canada Email Peter H Silverstone - peter.silverstone@ualberta.ca Emily C Bell - ebell@ualberta.ca Morgan C Willson - morgan.willson@med.ucalgary.ca Sanjay Dave - sanjay.dave@ualberta.ca Alan H Wilman - alan.wilman@ualberta.ca Corresponding author Published 19 July 2005 Received 06 June 2005 Annals of General Psychiatry 2005 4 14 doi 10.1186 1744-859X-4-14 Accepted 19 July 2005 This article is available from http www.annals-general-psychiatry.cOm content 4 1 14 2005 Silverstone et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background It is unknown if medications used to treat bipolar disorder have effects on brain activation and whether or not any such changes are mood-independent. Methods Patients with bipolar disorder who were depressed n 5 or euthymic n 5 were examined using fMRI before and 14 days after being started on lithium as monotherapy in 6 of these patients . Patients were examined using a word generation task and verbal memory task both of which have been shown to be sensitive to change in previous fMRI studies. Differences in blood oxygenated level dependent BOLD magnitude between the pre- and post-lithium results were determined in .