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Báo cáo y học: " γ δ Vγ9/Vδ2 T lymphocytes in Italian patients with Behçet’s disease – evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor β1 expression in active disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: γ δ Vγ9/Vδ2 T lymphocytes in Italian patients with Behçet’s disease – evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor β1 expression in active disease. | Arthritis Research Therapy Vol 5 No 5 Triolo et al. Research article Open Access Vy9 VS2 T lymphocytes in Italian patients with Behẹet s disease -evidence for expansion and tumour necrosis factor receptor II and interleukin-12 receptor P1 expression in active disease Giovanni Triolo1 Antonina Accardo-Palumbo2 Francesco Dieli2 Francesco Ciccia1 Angelo Ferrante1 Ennio Giardina1 Caterina Di Sano2 and Giuseppe Licata3 1Department of Internal Medicine Section of Rheumatology Clinical Immunology University of Palermo Palermo Italy 2Department of BioPathology Section of General Pathology University of Palermo Palermo Italy 3Department of Internal Medicine Division of Internal Medicine University of Palermo Palermo Italy Correspondence Giovanni Triolo e-mail triolog@tiscalinet.it Received 14 Nov 2002 Revisions requested 10 Feb 2003 Revisions received 10 Apr 2003 Accepted 15 May 2003 Published 30 Jun 2003 Arthritis Res Ther 2003 5 R262-R268 DOI 10.1186 ar785 2003 Triolo et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Behpet s disease is a multisystem disease in which there is evidence of immunological dysregulation. It has been proposed that y s T cells are involved in its pathogenesis. The aim of the present study was to assess the capacity of y s T cells with phenotype Vy9 VS2 from a group of Italian patients with Behpet s disease to proliferate in the presence of various phosphoantigens and to express tumour necrosis factor TNF and IL-12 receptors. Twenty-five patients and 45 healthy individuals were studied. Vy9 VS2 T cells were analyzed by fluorescence activated cell sorting utilizing specific monoclonal antibodies. For the expansion of Vy9 VS2 T cells lymphocytes were cultured in the presence of various phosphoantigens. The .