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Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: γ The role of the complement and the FcγR system in the pathogenesis of arthritis. | Available online http arthritis-research.eom contents 7 4 129 Review The role of the complement and the FcyR system in the pathogenesis of arthritis Samuel Solomon1 Daniela Kassahn1 and Harald Illges1 2 3 11mmunology Department of Biology Faculty of Sciences University of Konstanz Konstanz Germany 2Biotechnology Institute Thurgau Tagerwilen Switzerland 3University of Applied Sciences Department of Natural Sciences Immunology and Cell Biology Rheinbach Germany Corresponding author Harald Illges harald.illges@fh-brs.de Published 16 May 2005 This article is online at http arthritis-research.com content 7 4 129 2005 BioMed Central Ltd Abstract Autoantibodies in sera from patients with autoimmune diseases have long been known and have become diagnostic tools. Analysis of their functional role again became popular with the availability of mice mutant for several genes of the complement and Fcy receptor FcyR systems. Evidence from different inflammatory models suggests that both systems are interconnected in a hierarchical way. The complement system mediators such as complement component 5a C5a might be crucial in the communication between the complement system and FcYR-expressing cells. The split complement protein C5a is known to inactivate cells by its G-protein-coupled receptor and to be involved in the transcriptional regulation of FcyRs thereby contributing to the complex regulation of autoimmune disease. Introduction Rheumatoid arthritis RA is a severe chronic disease characterized by the inflammation of synovial tissue in joints which causes pain and dysfunction and ultimately leads to the destruction of joints. The pathogenesis of RA is not yet fully understood 1 2 . A general pathogenic hallmark of RA is the infiltration of T cells B cells macrophages granulocytes and particular neutrophils into the synovial lining and fluid and the periarticular spaces. These infiltrating cells produce abundant cytokines dominated mainly by the inflammatory type of cytokines .