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Báo cáo y học: "Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5α-reduced androgens"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5α-reduced androgens. | Available online http arthritis-research.eom content 7 5 R938 Research article Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes - androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5a-reduced androgens Martin Schmidt1 Claudia Weidler2 Heidrun Naumann1 Sven Anders3 Jurgen Scholmerich2 and Rainer H Straub2 institute of Biochemistry II Hospital of the Friedrich-Schiller-University Jena Germany 2Department of Internal Medicine I University Hospital Regensburg Regensburg Germany 3Department of Orthopedic Surgery University Regensburg Bavarian Red Cross Hospital Bad Abbach Germany Contributed equally Corresponding author Rainer H Straub rainer.straub@klinik.uni-regensburg.de Received 28 Feb 2005 Revisions requested 15 Apr 2005 Revisions received 7 May 2005 Accepted 17 May 2005 Published 10 Jun 2005 Arthritis Research Therapy 2005 7 R938-R948 DOI 10.11 86 ar1 769 This article is online at http arthritis-research.com content 7 5 R938 2005 Schmidt et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract In synovial cells of patients with osteoarthritis OA and rheumatoid arthritis RA conversion products of major antiinflammatory androgens are as yet unknown but may be proinflammatory. Therefore therapy with androgens in RA could be a problem. This study was carried out in order to compare conversion products of androgens in RA and OA synoviocytes. In 26 OA and 24 RA patients androgen conversion in synovial cells was investigated using radiolabeled substrates and analysis by thin-layer chromatography and HPLC. Aromatase expression was studied by immunohistochemistry. Dehydroepiandrosterone DHEA was converted into androstenediol androstenedione .