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Báo cáo y học: "Relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss. | Available online http arthritis-research.eom content 8 4 R98 Research article Relaxin and p-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages progesterone prevents matrix loss Gihan Hashem Qin Zhang Takayuki Hayami Jean Chen Wei Wang and Sunil Kapila Department of Orthodontics and Pediatric Dentistry University of Michigan 1011 North University Avenue Ann Arbor MI 48109-1 078 USA Corresponding author Sunil Kapila skapila@umich.edu Received 21 Mar 2006 Revisions requested 10 May 2006 Revisions received 17 May 2006 Accepted 25 May 2006 Published 19 Jun 2006 Arthritis Research Therapy 2006 8 R98 doi 10.1186 ar1 978 This article is online at http arthritis-research.com content 8 4 R98 2006 Hashem et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Relaxin a 6-kDa polypeptide hormone is a potent mediator of matrix turnover and contributes to the loss of collagen and glycosaminoglycans GAGs from reproductive tissues including the fibrocartilaginous pubic symphysis of several species. This effect is often potentiated by p-estradiol. We postulated that relaxin and p-estradiol might similarly contribute to the enhanced degradation of matrices in fibrocartilaginous tissues from synovial joints which may help explain the preponderance of diseases of specific fibrocartilaginous joints in women of reproductive age. The objective of this study was to compare the in vivo effects of relaxin p-estradiol and progesterone alone or in various combinations on GAG and collagen content of the rabbit temporomandibular joint TMJ disc fibrocartilage knee meniscus fibrocartilage knee articular cartilage and the pubic symphysis. Sham-operated or ovariectomized female rabbits were .