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Báo cáo y học: "DREAM is reduced in synovial fibroblasts of patients with chronic arthritic pain: is it a suitable target for peripheral pain management"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: DREAM is reduced in synovial fibroblasts of patients with chronic arthritic pain: is it a suitable target for peripheral pain management? | Available online http arthritis-research.eom content 10 3 R60 Research article DREAM is reduced in synovial fibroblasts of patients with chronic arthritic pain is it a suitable target for peripheral pain management Natasa Reisch1 2 Andrea Engler1 2 André Aeschlimann3 Beat R Simmen4 Beat A Michel1 2 Renate E Gay1 2 Steffen Gay1 2 and Haiko Sprott1 2 1Center of Experimental Rheumatology Department of Rheumatology and Institute of Physical Medicine University Hospital CH-8091 Zurich Gloriastrasse 25 Switzerland 2Center for Integrative Human Physiology University of Zurich CH-8057 Zurich Winterthurerstrasse 1 90 Switzerland 3RehaClinic CH-5330 Zurzach Quellenstrasse Switzerland 4Schulthess-Klinik CH-8008 Zurich Lengghalde 2 Switzerland Corresponding author Haiko Sprott haiko.sprott@usz.ch Received 23 Jan 2008 Revisions requested 13 Mar 2008 Revisions received 23 Apr 2008 Accepted 28 May 2008 Published 28 May 2008 Arthritis Research Therapy 2008 10 R60 doi 10.1186 ar2431 This article is online at http arthritis-research.com content 10 3 R60 2008 Reisch et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The endogenous pain-relieving system depends in part on the regulation of nociceptive signals through binding of opioids to the corresponding opioid receptor. Interfering with the trans-repression effect of downstream regulatory element antagonist modulator DREAM on the transcription of the opioid dynorphin-encoding prodynorphin pdyn gene might enhance pain relief in the periphery. Methods Expression levels were measured in osteoarthritis OA synovial fibroblast-like cells SFLCs n 8 and in peripheral blood mononuclear cells PBMCs from OA patients n 53 and healthy controls n 26 by real-time .