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Báo cáo y học: "Anti-inflammatory and arthritic effects of thiacremonone, a novel sulfurcompound isolated from garlic via inhibition of NF-κB"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Anti-inflammatory and arthritic effects of thiacremonone, a novel sulfurcompound isolated from garlic via inhibition of NF-κB. | Available online http arthritis-research.eom content 11 5 R145 Research article Anti-inflammatory and arthritic effects of thiacremonone a novel sulfurcompound isolated from garlic via inhibition of NF-kB Jung Ok Ban1 Ju Hoon Oh1 Tae Myoung Kim2 Dae Joong Kim2 Heon-Sang Jeong3 Sang Bae Han1 and Jin Tae Hong1 College of Pharmacy and Medical Research Center Chungbuk National University 12 Gaeshin-dong Heungduk-gu Cheongju Chungbuk 361763 Korea 2College of Veterinary Medicine Chungbuk National University 12 Gaeshin-dong Heungduk-gu Cheongju Chungbuk 361-763 Korea 3College of Agriculture Life and Environments Sciences Chungbuk National University 1 2 Gaeshin-dong Heungduk-gu Cheongju Chungbuk 361-763 Korea Corresponding author Jin Tae Hong jinthong@chungbuk.ac.kr Received 26 Dec 2008 Revisions requested 18 Feb 2009 Revisions received 17 Jul 2009 Accepted 30 Sep 2009 Published 30 Sep 2009 Arthritis Research Therapy 2009 11 R145 doi 10.11 86 ar2819 This article is online at http arthritis-research.com content 11 5 R145 2009 Ban et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Sulfur compounds isolated from garlic exert antiinflammatory properties. We recently isolated thiacremonone a novel sulfur compound from garlic. Here we investigated the anti-inflammatory and arthritis properties of thiacremonone through inhibition of NF-kB since NF-kB is known to be a target molecule of sulfur compounds and an implicated transcription factor regulating inflammatory response genes. Methods The anti-inflammatory and arthritis effects of thiacremone in in vivo were investigated in 12-O-tetradecanoylphorbol-13-acetate-induced ear edema carrageenan and mycobacterium butyricum-induced inflammatory and .