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Báo cáo y học: " N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD. | Respiratory Research BioMed Central Research N-a-PGP and PGP potential biomarkers and therapeutic targets for COPD Philip O Reilly 1 Patricia L Jackson2 Brett Noerager3 Suzanne Parker2 Mark Dransfield1 Amit Gaggar1 3 and J Edwin Blalock3 4 Open Access Address 1Division of Pulmonary and Critical Care Medicine University of Alabama at Birmingham THT 422 1900 University Blvd Birmingham Alabama 35294-0006 USA 2Department of Pathology University of Alabama at Birmingham MCLM 894 1918 University Blvd Birmingham Alabama 35294-0005 USA 3Department of Physiology and Biophysics University of Alabama at Birmingham MCLM 894 1918 University Blvd Birmingham Alabama 35294-0005 USA and 4Division of Pharmacology and Pathophysiology Department of Pharmaceutical Sciences Faculty of Science Utrecht University Utrecht the Netherlands Email Philip O Reilly - poreilly@uab.edu Patricia L Jackson - plj@uab.edu Brett Noerager - bnoerager@montevallo.edu Suzanne Parker - szparker@uab.edu Mark Dransfield - mdransfield99@msn.com Amit Gaggar - amitgaggar@yahoo.com J Edwin Blalock - blalock@uab.edu Corresponding author Published 18 May 2009 Received 5 January 2009 Respiratory Research 2009 10 38 doi l0.ll86 l465-992l-l0-38 Accepted 18 May 2009 This article is available from http respiratory-research.cOm content l0 l 38 2009 O Reilly et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Chronic obstructive pulmonary disease COPD is a common respiratory disorder for which new diagnostic and therapeutic approaches are required. Hallmarks of COPD are matrix destruction and neutrophilic airway inflammation in the lung. We have previously described two tri-peptides N-a-PGP and PGP which are collagen fragments and neutrophil chemoattractants.