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Báo cáo y học: " Limited β2-adrenoceptor haplotypes display different agonist mediated airway responses in asthmatics"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Limited β2-adrenoceptor haplotypes display different agonist mediated airway responses in asthmatics. | Respiratory Research BioMed Central Research Open Access Limited P2-adrenoceptor haplotypes display different agonist mediated airway responses in asthmatics Anneke van Veen1 Eddy A Wierenga2 Robert Westland2 Frank R Weller1 Guus AM Hart3 Henk M Jansen1 and René E Jonkers 1 Address Department of Pulmonology Academic Medical Centre University of Amsterdam Amsterdam The Netherlands 2Department of Cell Biology and Histology Academic Medical Centre University of Amsterdam Amsterdam The Netherlands and 3Department of Epidemiology and Biostatistics Academic Medical Centre University of Amsterdam Amsterdam The Netherlands Email Anneke van Veen - a.vanveen@amc.uva.nl Eddy A Wierenga - e.a.wierenga@amc.uva.nl Robert Westland - r.westland@amc.uva.nl Frank R Weller - fweller@heideheuvel.nl Guus AM Hart - a.a.hart@amc.uva.nl Henk M Jansen - h.m.jansen@amc.uva.nl René E Jonkers - r.e.jonkers@amc.uva.nl Corresponding author Published 31 January 2006 Received 28 June 2005 Respiratory Research 2006 7 19 doi l0.ll86 l465-992l-7-l9 Accepted 31 January 2006 This article is available from http respiratory-research.cOm content 7 l l9 2006 van Veen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In vitro and some in vivo studies suggested that genetic haplotypes may have an impact on P2-agonist mediated airway responses in asthmatics. Due to strong linkage disequilibrium the single nucleotide polymorphisms SNPs in the P2-adrenoceptor gene result in only a limited number of haplotypes. We intended to evaluate the impact of P2-adrenoceptor haplotypes on P2-agonist mediated airway responses and the development of tolerance in mild to moderate asthmatics. Methods Patients were genotyped for the part of the P2-adrenoceptor .