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Báo cáo y học: " Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-β"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-β. | Respiratory Research BioMed Central Research Open Access Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-p Sybille van den Brule 1 Pierre Misson1 Frank Buhling2 Dominique Lison1 and Francois Huaux1 Address 1Unit of Industrial Toxicology and Occupational Medicine Université catholique de Louvain Clos Chapelle-aux-Champs 30.54 1200 Brussels Brussels Belgium and 2Institute of Immunology Otto-von-Guericke-University Magdeburg Leipziger-Str. 44 39120 Magdeburg Germany Email Sybille van den Brule - Sybille.VandenBrule@toxi.ucl.ac.be Pierre Misson - Pierre-Damien.Misson@toxi.ucl.ac.be Frank Buhling - F.Buehling@ctk.de Dominique Lison - lison@toxi.ucl.ac.be Francois Huaux - huaux@toxi.ucl.ac.be Corresponding author Published 27 July 2005 Received 25 February 2005 Respiratory Research 2005 6 84 doi 10.1186 1465-9921 -6-84 Accepted 27 July 2005 This article is available from http respiratory-research.eom content 6 1 84 2005 van den Brule et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Lung fibrosis is characterized by tissue remodeling resulting from an imbalance between synthesis and degradation of extracellular organic matrices. To examine whether cathepsin s Cat are important in the development of pulmonary fibrosis we assessed the expression of four Cat known for their collagenolytic activity in a model of silica-induced lung fibrosis. Methods Different strains of mice were transorally instilled with 2.5 mg crystalline silica or other particles. Cat expression Cat K S L and B was quantified in lung tissue and isolated pulmonary cells by quantitative RT-PCR. In vitro we assessed the effect of different cytokines involved in lung inflammatory and fibrotic responses on .