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BEHAVIOR ANALYSIS in NEUROSCIENCE - PART 10

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Trong nhiệm vụ phân biệt đối xử màu sắc và vị trí (CPR), tính chính xác của những con khỉ có thể so sánh với trẻ em từ 6 tuổi trở lên, tỉ lệ đáp ứng trong khi con khỉ trong nhiệm vụ này là tương tự như những người từ 5 đến 6 trẻ em tuổi. Độ chính xác học tập nhiệm vụ | children. In the color and position discrimination task CPR the accuracy of monkeys is comparable to that of children 6 and older whereas monkey response rates in this task are similar to those of 5 to 6 year old children. Accuracy of learning task IRA performance for monkeys is comparable to that of 5-year-old children while IRA response rates for monkeys are generally greater than those for even 12 to 13 year old children. There are thus clear differences in the patterns of OTB performance between monkeys and children but in all cases examined well-trained monkeys perform as well as or better than children aged 4 years and older. The use of the NCTR OTB in the monkey laboratory produces information both relevant to and predictive of important aspects of brain function in humans. The degree to which monkey behavior can serve as a surrogate for the study of human brain function and dysfunction remains to be determined. Application of similar behavioral techniques in other animal models may identify additional surrogate species. Likewise the application of different behavioral techniques should provide surrogates for additional brain functions. References 1. Schulze G. E. McMillan D. E. Bailey J. R. Scallet A. C. Ali S. F. Slikker W. Jr. and Paule M. G. Acute effects of delta-9-tetrahydrocannabinol THC in rhesus monkeys as measured by performance in a battery of cognitive function tests J. Pharmacol. Exp. Ther 245 1 178 1988. 2. Schulze G. E. McMillan D. E. Bailey J. R. Scallet A. C. Ali S. F. Slikker W. Jr. and Paule M. G. Acute effects of marijuana smoke on complex operant behavior in rhesus monkeys Life Sciences 45 6 465 1989. 3. Paule M. G. Schulze G. E. and Slikker W. Jr. Complex brain function in monkeys as a baseline for studying the effects of exogenous compounds Neurotoxicology 9 3 463 1988. 4. Morris P. Gillam M. P. Allen R. R. and Paule M. G. The effects of chronic cocaine exposure during pregnancy on the acquisition of operant behaviors by rhesus monkey