Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Ilizarov treatment of humeral shaft nonunion in an antiepileptic drug patient with uncontrolled generalized tonic-clonic seizure activity | Sioros et al. Journal of Orthopaedic Surgery and Research 2010 5 48 http content 5 1 48 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH CASE REPORT Open Access Ilizarov treatment of humeral shaft nonunion in an antiepileptic drug patient with uncontrolled generalized tonic-clonic seizure activity -5ciIdicsc c Qic rc ct Ct I Liccoc t - lirc tric P ìfìl ìc Poroox icstic IXí-ii lie ll . .ii d ilc iie lrc i l lo rc c lr iotir lict Vdsileios S Sioros Mdnos G Lykissds Dimitrios rdlilds rdndyiolis KUUlUUvdlls Alexdllcuos N IVIdvIUUUl UlUls Abstract Nonunion of the humerdl shdft in pdlienls with dnliepileplic drug dssocidled meldbolic bone disorder conslilule d chdllenging surgicdl problem difficult to tredl due to seizure dctivity osteoporosis dnd poor sldbilizdlion options. We report d cdse of nonunion of the humerdl shdfl in dn dnliepileplic drug pdlienl with uncontrolled generalized tonic-clonic seizure dclivily successfully lredled with Ilizdrov exlerndl fixdlor dnd d follow-up of 4 yedrs. Background Humeral shaft fractures account for approximately of all fractures 1 . Approximately 1-15 of these fractures progress to nonunion 2-7 . Nonunion of the humeral shaft in patients with antiepileptic drug associated metabolic bone disorder constitute a challenging surgical problem difficult to treat due to seizure activity osteoporosis and poor stabilization options. Treatment options include internal fixation supplemented with cancellous bone graft intramedullary nailing free vascularized fibular graft and Ilizarov circular frame fixation. At the hands of an expert surgeon Ilizarov external thin-wire fixator can be a viable surgical option for the treatment of humeral shaft nonunion. We report a case of nonunion of the humeral shaft in an antiepileptic drug patient with uncontrolled generalized tonic-clonic seizure activity successfully treated with Ilizarov external fixator and a follow-up of 4 years. Case presentation A 43-year-old man was admitted to
