It is worth emphasising however that we now appear to have a range of compounds that in some patients at least, and for some time, help to control positive psychotic symptoms. While this is very important, this benefit may come with associated adverse consequences in other ways for some patients, such as cardio-metabolic side effects that can have a major impact on physical health. Clinicians therefore will need to exercise careful and skilled judgement about which antipsychotic to use in order to benefit individual patient’s symptoms, and minimise adverse health effects. There is real scope for the pharmaceutical industry to.