A 55-year-old woman presented with a 3-year history of gradually progressive postprandial epigastric fullness. Esophagogastroduodenoscopy revealed a large, broad-based mass in the medial wall of the duodenal bulb (Figure 1). Endoscopic ultrasound showed a large, hyperechoic lesion originating from the submucosal layer of the duodenal wall consistent with a lipoma, and computed tomography of the abdomen with contrast suggested the presence of a homogeneous mass with uniform fat density in the duodenal bulb (Figure 2). Endoloop (Olympus Optical Co, Ltd, Japan) ligation was performed with a double-channel therapeutic upper endoscope (GIF-190, Olympus) deployed in 3 steps (loop placement, tightening, and detachment; Video 1 [watch the video at ]). The mass was positioned in the 6-o’clock position to aid loop placement around the base of the broad stalk. The loop was tightened until a dark color change indicating strangulation and congestion was seen. After adequate tightening via the loop handle, the loop was detached by pushing the slider forward (Figure 3). Diluted epinephrine 1:10,000 was injected into the base of the stalk and the tumor was completely resected above the loop using a snare cautery, and hemoclips were placed at the base for additional hemostasis. The resected tumor measured approximately 5 3 4 cm. Histopathological examination revealed a well-differentiated adipose tumor (lipoma), which was completely covered by a fibrous capsule (Figure 4). There were no complications related to the procedure. No residual tissue was observed on repeat endoscopic examination after 1 month, and the patient remained asymptomatic. | Endoscopic resection of a giant duodenal lipoma
