This method is associated with some attractive characteristics such as good selectivity, very short reaction time, high yield of products, cleaner reaction profile,no harmful by-product, cheap and environmental benign catalyst, simple experimental andwork-up procedure. This procedure does not require solvent separation and purification stepssuch as column chromatography. | A green chemoselective one-pot protocol for expeditious synthesis of symmetric pyranodipyrimidine derivatives using Current Chemistry Letters 5 2016 145 154 Contents lists available at GrowingScience Current Chemistry Letters homepage A green chemoselective one-pot protocol for expeditious synthesis of symmetric pyranodipyrimidine derivatives using Mehdi Rimaza Hossein Mousavia Mojgan Behnama and Behzad Khalilib a Department of Chemistry Payame Noor University PO Box 19395-3697 Tehran Iran b Department of Chemistry Faculty of Sciences University of Guilan . Box 41335-1914 Rasht Iran CHRONICLE ABSTRACT Article history A convenient highly efficient and time economic method has been described for the chemo- Received January 21 2016 and regioselective synthesis of 5-aryloyl-1 3 7 9-tetraalkyl-2 8-dithioxo-2 3 8 9-tetrahydro- Received in revised form 1H-pyrano 2 3-d 6 5-dˊ dipyrimidine-4 6 5H 7H -diones derivatives by one-pot two- July 10 2016 component reaction of 1 3-diethyl-2-thiobarbituric acid or 1 3-dimethyl-2-thiobarbituric acid Accepted 18 August 2016 with substituted arylglyoxalmonohydrates using commercially available zirconium IV Available online oxydichloride octahydrate as green Lewis acid catalyst. This method is 18 August 2016 associated with some attractive characteristics such as good selectivity very short reaction Keywords time high yield of products cleaner reaction profile no harmful by-product cheap and Lewis-acid catalysis Green chemistry environmental benign catalyst simple experimental and work-up procedure. This procedure Pyranopyrimidine does not require solvent separation and purification steps such as column chromatography. Arylglyoxal One-pot synthesis 2016 Growing Science Ltd. All rights reserved. 1. Introduction Synthesis of required products in selective and environmentally friendly way is an enduring challenge in chemical sciences. Thus in recent times Green Chemistry which
