The work has been carried out under thermal solvent free conditions. Mg/Fe = 3 hydrotalcite heterogeneous solid catalyst offers simple means of recovery and the isolated catalyst was reused for number of times without significant loss of catalytic activity. | One-pot solvent free synthesis of dihydropyrimidinones using calcined Mg Fe hydrotalcite catalyst Current Chemistry Letters 6 2017 77 90 Contents lists available at GrowingScience Current Chemistry Letters homepage One-pot solvent free synthesis of dihydropyrimidinones using calcined Mg Fe hydrotalcite catalyst Vijay V Dabholkara Keshav S Badheb and Swapnil K Kuradec a b c Organic Research Laboratory Department of Chemistry Guru Nanak College Nagar Mumbai-400 037 India CHRONICLE ABSTRACT Article history The Mg Fe 3 hydrotalcite as reusable solid catalyst was found to be an excellent Received August 21 2016 heterogeneous base catalyst for the synthesis of 3 4-dihydropyrimidinones thiones a Received in revised form multicomponent reaction using substituted aromatic aldehyde ethyl acetoacetate and October 24 2016 urea thiourea. The work has been carried out under thermal solvent free conditions. Mg Fe Accepted 17 November 2016 3 hydrotalcite heterogeneous solid catalyst offers simple means of recovery and the isolated Available online catalyst was reused for number of times without significant loss of catalytic activity. 17 November 2016 Keywords Hydrotalcite Dihydropyrimidinone Aromatic aldehydes Multicomponent reactions Heterogeneous catalysis 2017 Growing Science Ltd. All rights reserved. 1. Introduction Dihydropyrimidinone and their derivatives are one of the prime interests because of their promising biological and pharmacological activities such as antihypertensive reagent 1 antimicrobial 2 anti- inflammatory 3 antifungal 4 and calcium channel In addition they also act as an anticancer agent 6 and anti-HIV Therefore synthesis of this type of heterocyclic compound is of much current importance. MCR s is the efficient tools in the modern organic synthetic chemistry in view of their significant features such as atom economy straightforward reaction designing. MCR drawn great interests in the synthesis of biological
