Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13. | Available online http content 11 2 R41 Research article Protective effects of total fraction of avocado soybean unsaponifiables on the structural changes in experimental dog osteoarthritis inhibition of nitric oxide synthase and matrix metalloproteinase-13 Christelle Boileau1 Johanne Martel-Pelletier1 Judith Caron1 Philippe Msika2 Georges B Guillou2 Caroline Baudouin2 and Jean-Pierre Pelletier1 Open Access Osteoarthritis Research Unit University of Montreal Hospital Centre CRCHUM Notre-Dame Hospital Sherbrooke Street East Montreal Quebec H2L 4M1 Canada 2Laboratoires Expanscience Avenue de l Arche 9241 9 Courbevoie Cedex France Corresponding author Jean-Pierre Pelletier dr@ Received 19 Dec 2008 Revisions requested 12 Feb 2009 Revisions received 11 Mar 2009 Accepted 16 Mar 2009 Published 16 Mar 2009 Arthritis Research Therapy 2009 11 R41 doi ar2649 This article is online at http content 11 2 R41 2009 Boileau et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The aims of this study were first to investigate the in vivo effects of treatment with avocado soybean unsaponifiables on the development of osteoarthritic structural changes in the anterior cruciate ligament dog model and second to explore their mode of action. Methods Osteoarthritis was induced by anterior cruciate ligament transection of the right knee in crossbred dogs. There were two treatment groups n 8 dogs group in which the animals received either placebo or avocado soybean unsaponifiables 10 mg kg per day which were given orally for the entire duration of the study 8 weeks . We conducted macroscopic and histomorphological analyses of cartilage and subchondral bone of .
