Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Research In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer's disease. | Ul-Haq et al. Theoretical Biology and Medical Modelling 2010 7 22 http content 7 1 22 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access In silico modeling of the specific inhibitory potential of thiophene-2 3-dihydro-1 5-benzothiazepine against BChE in the formation of p-amyloid plaques associated with Alzheimer s disease Zaheer Ul-Haq 1 Waqasuddin Khan1 Saima Kalsoom2 and Farzana L Ansari2 Correspondence 1 Dr. Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological Sciences University of Karachi Karachi 75270 Pakistan Full list of author information is Abstract Background Alzheimer s disease known to be associated with the gradual loss of memory is characterized by low concentration of acetylcholine in the hippocampus and cortex part of the brain. Inhibition of acetylcholinesterase has successfully been used as a drug target to treat Alzheimer s disease but drug resistance shown by butyrylcholinesterase remains a matter of concern in treating Alzheimer s disease. Apart from the many other reasons for Alzheimer s disease its association with the genesis of fibrils by p-amyloid plaques is closely related to the increased activity of butyrylcholinesterase. Although few data are available on the inhibition of butyrylcholinesterase studies have shown that that butyrylcholinesterase is a genetically validated drug target and its selective inhibition reduces the formation of p-amyloid plaques. Rationale We previously reported the inhibition of cholinesterases by 2 3-dihydro-1 5-benzothiazepines and considered this class of compounds as promising inhibitors for the cure of Alzheimer s disease. One compound from the same series when substituted with a hydroxy group at C-3 in ring A and 2-thienyl moiety as ring B showed greater activity against butyrylcholinesterase than to acetylcholinesterase. To provide insight into the binding mode of this compound Compound A molecular .