Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: pG island density and its correlations with genomic features in mammalian genomes. | Research Open Access CpG island density and its correlations with genomic features in mammalian genomes Leng Han Bing Su Wen-Hsiung Li and Zhongming Zhao Addresses Department of Psychiatry Virginia Commonwealth University Richmond VA 23298 USA. State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China. Graduate School Chinese Academy of Sciences Beijing 100039 China. Kunming Primate Research Center Chinese Academy of Sciences Kunming Yunnan 650223 China. Department of Ecology and Evolution University of Chicago Chicago IL 60637 USA. Department of Human Genetics and Center for the Study of Biological Complexity Virginia Commonwealth University Richmond VA 23284 USA. Correspondence Zhongming Zhao. Email zzhao@ Published 13 May 2008 Genome Biology 2008 9 R79 doi 186 gb-2008-9-5-r79 The electronic version of this article is the complete one and can be found online at http 2008 9 5 R79 Received 7 April 2008 Revised 8 April 2008 Accepted 1 3 May 2008 2008 Han et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background CpG islands which are clusters of CpG dinucleotides in GC-rich regions are considered gene markers and represent an important feature of mammalian genomes. Previous studies of CpG islands have largely been on specific loci or within one genome. To date there seems to be no comparative analysis of CpG islands and their density at the DNA sequence level among mammalian genomes and of their correlations with other genome features. Results In this study we performed a systematic analysis of CpG islands in ten mammalian genomes. We found that both the number of CpG islands and their density vary
