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Basic medical endocrinology - part 1

Gần một thập kỷ trôi qua giữa công bố các phiên bản thứ hai và thứ ba của Y khoa Nội tiết cơ bản do một phần lớn cuộc khủng hoảng trong ngành công nghiệp xuất bản bằng consolidation.Although lớn mang lại phiên bản này là mới và nhà xuất bản là mớ | THIRD EDITION PREFACE Nearly a decade elapsed between publication of the second and third editions of Basic Medical Endocrinology due in large part to the turmoil in the publishing industry brought on by massive consolidation.Although this edition is new and the publisher is new the aims of earlier editions of this work are unchanged. Its focus remains human endocrinology with an emphasis on cellular and molecular mechanisms presented in the context of integration of body functions.The intent is to provide a sufficient level of understanding of normal endocrine physiology to prepare students to study not only endocrine diseases but also the cellular and molecular alterations that disrupt normal function. Such understanding is a prerequisite for institution of rational diagnostic procedures therapeutic interventions and research strategies. It is further hoped that this text provides the necessary background to facilitate continuing self-education in endocrinology. A decade is a long time in this remarkable era of modern biology. Whole new vistas of inquiry have been opened since the previous edition of this text appeared and new discoveries have mandated reinterpretation of many areas that were once thought to be solidly understood. Much of the progress of the past decade must be credited to ingenious application of rapidly evolving technology in molecular biology. Studies of gene expression and the charting of the genomes of several species including our own has provided a deluge of new information and new insights. The exquisite sensitivity and versatility of this technology has uncovered both hormone production and hormone receptors in unexpected places and revealed hitherto unappreciated roles for classical hormones. Classical techniques of organ ablation and extract injection have been reapplied using the once unthinkable technology of gene ablation or overexpression to explore the functions of individual proteins instead of individual glands. The decade has .