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báo cáo khoa học: "Metastatic gallbladder adenocarcinoma with signet-ring cells: A case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Metastatic gallbladder adenocarcinoma with signet-ring cells: A case report | Bazan et al. Journal of Medical Case Reports 2011 5 458 http www.jmedicalcasereports.eom content 5 1 458 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Metastatic gallbladder adenocarcinoma with signet-ring cells A case report 1 1 1 1 1 I-1 J 1 Fernando Bazan Juan Sanchez Guadalupe Aguilar Aleksandar Radosevic Marcos Busto Flavio Zuccarino Lara Pijuan2 and Noelia Risueno1 Abstract Introduction Signet-ring cell carcinoma is a rare and aggressive variant of mucinous adenocarcinoma. Only a few cases of gallbladder adenocarcinoma with signet-ring cells have been reported and because of this there is a lack of knowledge about the behavior and biology of this pathology. Case presentation We present the case of a 63-year-old Arab man with gallbladder signet-ring cell adenocarcinoma. He had an elective cholecystectomy and refused chemotherapy. Two months later a small hepatic metastatic nodule was found and nine months later he presented with multiple metastases in the liver lymphatic nodes both pleuras peritoneum and subcutaneous tissue. Conclusion The proliferation of signet-ring cells in a gallbladder adenocarcinoma worsens the prognosis of an already adverse neoplasm. New lines of treatment in chemotherapy such as cisplatin or new biological therapy such as monoclonal antibody c-myc oncogene should be encouraged to improve the survival and life quality of these oncologic patients. Introduction Gallbladder carcinoma GC is the fifth most common malignant tumor of the gastrointestinal tract and the most frequent malignant neoplasm of the biliary tract 1 . Approximately 99 of gallbladder cancers are carcinomas including 90 of adenocarcinomas mostly well or moderately differentiated 74 . Five percent of gallbladder carcinomas comprise other subtypes such as papillary adenocarcinomas squamous cell carcinomas and mucinous adenocarcinomas 1 . Signet-ring cell carcinoma SRCC is a rare and aggressive variant of mucinous adenocarcinoma. It is histologically characterized