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Báo cáo y học: " Sarcoid reaction associated with Merkel cell carcinoma revealed by fluorodeoxyglucose positron emission tomography: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Sarcoid reaction associated with Merkel cell carcinoma revealed by fluorodeoxyglucose positron emission tomography: a case report. | Higashi et al. Journal of Medical Case Reports 2011 5 282 http www.jmedicalcasereports.eom content 5 1 282 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Sarcoid reaction associated with Merkel cell carcinoma revealed by fluorodeoxyglucose positron emission tomography a case report 1 1 1 11 1 Yuko Higashi Kentaro Mera Mitsuyoshi Shimokawa Mitsuhiro Hisadome Atsunori Baba Shigeto Matsushita Masakazu Yanagi2 and Takuro Kanekura1 Abstract Introduction Although the association between cancer and sarcoidosis or sarcoid reaction is known sarcoid reaction associated with Merkel cell carcinoma is rare. Case presentation We report the case of a 57-year-old Japanese woman with Merkel cell carcinoma in the inguinal area associated with sarcoid reaction. Fluorodeoxyglucose positron emission tomography demonstrated elevated fluorodeoxyglucose uptake by mediastinal lymph nodes and at the carcinoma site. Histopathologically the mediastinal lymph nodes contained no Merkel cell carcinoma components. Sarcoid lesions were identified. Systemic examinations returned no sarcoidosis-specific findings. Conclusion Fluorodeoxyglucose positron emission tomographic scans can be used to assess neoplastic lesions and depict sarcoidosis. Sarcoid reactions must be considered in the interpretation of fluorodeoxyglucose positron emission tomographic scans. Introduction Sarcoidosis a common systemic disorder of unknown etiology is characterized by the formation of non-caseat-ing epithelioid cell granulomas. The lungs lymph nodes liver spleen skin eyes small bones of the hands and feet and the salivary glands are most often affected 1 . A diagnosis of sarcoid reaction is made when localized epithelioid granulomas are found without signs of systemic sarcoidosis. They are attributable to infections foreign materials gastrointestinal diseases and malignant tumors 1 . The reported incidence of sarcoid reactions in carcinoma is 4.4 in squamous cell carcinoma of the skin and mucous membranes it is