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Báo cáo y học: " Mannose-binding lectin deficiency with eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in children: a case series"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Mannose-binding lectin deficiency with eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in children: a case series. | Padilla-Docal et al. Journal of Medical Case Reports 2011 5 330 http www.jmedicalcasereports.eom content 5 1 330 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Mannose-binding lectin deficiency with eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in children a case series Barbara Padilla-Docal1 Alberto J Dorta-Contreras1 Raisa Bu-Coifiu-Fanego1 René H Martinez-Alderete1 Olga Susana de Paula-Almeida1 Hansotto Reiber2 and Jens Christian Jensenius3 Abstract Introduction Eosinophilic meningitis a potentially fatal disease caused by Angiostrongylus cantonensis is considered an emerging infectious disease. Case presentation Three Caucasian boys aged five-years-old 10-years-old and six-years-old with a diagnosis of eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis were studied. Serum immunoglobulin A IgA IgM IgG and complements C3c and C4 levels were quantified by using an immunodiffusion technique. Immunoglobulin E in serum was quantified by nephelometry and mannose-binding lectin by time-resolved fluorometry. Mannose-binding lectin deficiency was observed in the three patients. The first patient showed a reduction in the levels of IgA and IgM and an increase in the values of IgE and C4. The second patient showed a reduction in mannose-binding lectin level with increased IgG C4 and IgE levels and the third patient showed a decrease in mannose-binding lectin level and increased levels of IgM and complement C3c as well as a low level of C4. Conclusions To the best of our knowledge this is the first report of mannose-binding lectin deficiency associated with Angiostrongylus cantonensis meningoencephalitis in children and it may contribute to the understanding of the participation of this component of the lectin pathway in the development of the disease. Introduction Eosinophilic meningitis a potentially fatal disease caused by Angiostrongylus cantonensis a parasitic nematode is considered an emerging infectious disease 1 .