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báo cáo khoa học: "Canine parvovirus-like particles, a novel nanomaterial for tumor targeting"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Canine parvovirus-like particles, a novel nanomaterial for tumor targeting | Journal of Nanobiotechnology BioMed Central Research Open Access Canine parvovirus-like particles a novel nanomaterial for tumor targeting Pratik Singh1 2 Giuseppe Destito1 2 4 Anette Schneemann1 3 and Marianne Manchester 1 2 Address Center for Integrative Molecular Biosciences The Scripps Research Institute La Jolla CA 92037 USA 2Department of Cell Biology The Scripps Research Institute La Jolla CA 92037 USA 3Department of Molecular Biology The Scripps Research Institute La Jolla CA 92037 USA and 4Dipartimento di Medicina Sperimentale e Clinica Università degli Studi Magna Graecia di Catanzaro Campus Universitario di Germaneto Catanzaro ITALY Email Pratik Singh - prasingh@scripps.edu Giuseppe Destito - giuseppe@scripps.edu Anette Schneemann - aschneem@scripps.edu Marianne Manchester - marim@scripps.edu Corresponding author Received 14 September 2005 Accepted 13 February 2006 Published 13 February 2006 Journal of Nanobiotechnology 2006 4 2 doi 10.1186 1477-3155-4-2 This article is available from http www.jnanobiotechnology.cOm content 4 1 2 2006 Singh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Specific targeting of tumor cells is an important goal for the design of nanotherapeutics for the treatment of cancer. Recently viruses have been explored as nano-containers for specific targeting applications however these systems typically require modification of the virus surface using chemical or genetic means to achieve tumor-specific delivery. Interestingly there exists a subset of viruses with natural affinity for receptors on tumor cells that could be exploited for nanotechnology applications. For example the canine parvovirus CPV utilizes transferrin receptors TfRs for binding and cell entry into canine as