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báo cáo khoa học: "Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway | Journal of Nanobiotechnology BioMed Central Research Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8 AIF mediated cytochrome c-independent pathway Jinshun Zhao1 Linda Bowman1 Xingdong Zhang1 Xianglin Shi2 Binghua Jiang3 Vincent Castranova1 and Min Ding 1 Open Access Address Pathology and Physiology Research Branch Health Effects Laboratory Division National Institute for Occupational Safety and Health Morgantown WV 26505 USA 2Graduate Center for Toxicology College of Medicine the University of Kentucky Lexington KY 40515 USA and 3Department of Microbiology Immunology and Cell Biology West Virginia University Morgantown WV 26505 USA Email Jinshun Zhao - fyq9@cdc.gov Linda Bowman - llb2@cdc.gov Xingdong Zhang - xaz5@cdc.gov Xianglin Shi - xshi5@email.uky.edu Binghua Jiang - bhjiang@hsc.wvu.edu Vincent Castranova - vic1@cdc.gov Min Ding - mid5@cdc.gov Corresponding author Published 20 April 2009 Received 21 January 2009 _ .rK.AAAO 71 j.uAiioz mTiinm Accepted 20 April 2009 Journal of Nanobiotechnology 2009 7 2 doi 10.1186 1477-3155-7-2 This article is available from http www.jnanobiotechnology.cOm content 7 1 2 2009 Zhao et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Carcinogenicity of nickel compounds has been well documented. However the carcinogenic effect of metallic nickel is still unclear. The present study investigates metallic nickel nano- and fine particle-induced apoptosis and the signal pathways involved in this process in JB6 cells. The data obtained from this study will be of benefit for elucidating the pathological and carcinogenic potential of metallic nickel particles. Results Using 3- 4 5-dimethylthiazol-2-yl -2 5-diphenyltetrazolium bromide .