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báo cáo khoa học: " A potential tocopherol acetate loaded palm oil esters-in-water nanoemulsions for nanocosmeceuticals"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A potential tocopherol acetate loaded palm oil esters-in-water nanoemulsions for nanocosmeceuticals | Teo et al. Journal of Nanobiotechnology 2010 8 4 http www.jnanobiotechnology.eom content 8 1 4 JOURNAL OF NANOBIOTECHNOLOGY RESEARCH Open Access A potential tocopherol acetate loaded palm oil esters-in-water nanoemulsions for nanocosmeceuticals Brian Sheng Xian Teo1 Mahiran Basri1 Mohd Rezuwan Shah Zakaria Abu Bakar Salleh2 Raja Noor Zaliha Raja Abdul Rahman3 Mohd Basyaruddin Abdul Rahman1 Abstract Background Cosmeceuticals are cosmetic-pharmaceutical hybrids intended to enhance health and beauty of the skin. Nanocosmeceuticals use nano-sized system for the delivery of active ingredients to the targeted cells for better penetration. In this work nanoemulsion from palm oil esters was developed as a delivery system to produce nanocosmeceuticals. The stability of the resulting formulation was tested using various methods. In addition the effect of components i.e. Vitamin E and Pluronic F-68 on the formulation was also studied. Results Both vitamin E and Pluronic F-68 were found to co-emulsify and co-stabilized the formulations. The best formulation was found to be the one having the composition of 10 Palm Oil Esters POEs 10 vitamin E 24 Tween 80 2.4 Pluronic F-68 and 53.6 deionised water. Those compositions are considered to be the best as a nanocosmeceutical product due to the small particle size 94.21 nm low occurrence of Ostwald ripening and stable at different storing temperatures 5 25 and 45 C for four weeks. Conclusions Palm oil esters-in-water nanoemulsions loaded with vitamin E was successfully formulated and has the potential for the use as nanocosmeceuticals. Introduction Palm oil esters POEs are specialty esters and are emerging oleochemicals in Malaysia as the world s largest exporter and producer of palm oil. In 2008 Malaysia produced 17.73 million tonnes of crude palm oil and 2.13 million tonnes of crude palm kernel oil 1 2 . POEs are wax est ers of long chain fatty acids from palm oil esterified with long chain alcohol and have promising revenue as they