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Advanced therapy in thoracic surgery - part 8

Ghép Tim Phổi năm 1993; 12 (Pt 1) :5-15, thảo luận 15-6. 16. Struber M, Wilhelmi M, Harringer W, et al. Tưới máu tuôn ra với giải pháp dextran kali thấp cải thiện chức năng ghép đầu trong cấy ghép phổi lâm sàng. | Lung Retransplantation 385 15. Novick RJ Kaye MP Patterson GA et al. Redo lung transplantation a North American-European experience. J Heart Lung Transplant 1993 12 Pt 1 5-15 discussion 15-6. 16. Struber M Wilhelmi M Harringer W et al. Flush perfusion with low potassium dextran solution improves early graft function in clinical lung transplantation. Eur J Cardiothorac Surg 2001 19 190-4. 17. Fischer S Matte-Martyn A De Perrot M et al. Low-potassium dextran preservation solution improves lung function after human lung transplantation. J Thorac Cardiovasc Surg 2001 121 594-6. 18. Pierre AF Sekine Y Hutcheon MA et al. Marginal donor lungs a reassessment. J Thorac Cardiovasc Surg 2002 123 421-7 discussion 427-8. Chapter 31 Lung Xenotransplantation Lessons Learned and Future Perspectives Carsten Schroder md Paolo Macchiarini md PhD Success of clinical allotransplantation as a therapeutic option for end-stage kidney heart lung and liver disease has resulted in the worldwide diffusion of this life-saving treatment. However since there are not enough cadaveric organs to meet the present clinical demand it has also actualized the growing problem of donor organ availability. Despite this shortfall which affects all organs the disparity between the supply and demand for organs is most acute for the lung. According to the 2002 United Network for Organ Sharing registry 3 822 patients are waiting on the recipient list in the united states for lung transplantation and only about 1 000 of these patients will receive transplants. The reasons for this frustrating scenario are the unique susceptibility of lungs to damage induced by the brain-dead treatment the marginal yearly increase of donor lungs and the growing number of teams performing lung transplantation. As expected access to the waiting lists is currently very restricted patients in need of lungs are waiting approximately twice as long today as in 1990 the median waiting period is 7 months for patients younger than age 16 .