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TREATMENT OF BIPOLAR DISORDER IN CHILDREN AND ADOLESCENTS - PART 10

Chống loạn thần không điển hình (N = 10, n = 225) tác giả (s) (năm) Thiết kế 30 10.6 (17/06) 8 (NR) 26,7 1,2 ± 1,5 2,1 ± 2,0 Age Na trong những năm (phạm vi) Dropout cơ bản: Liều lượng (%) (mg / ngày) tăng cân (kg) Biederman, Mick CV, Wozniak (2005) chống loạn thần, tâm trạng ổn định điều trị kết hợp | 374 TABLE 18.5. continued Atypical antipsychotic N 10 n 225 First author s year Design Na Age in years range Duration in weeks mean Dropout Dose Weight gain kg Comparator p mg day Biederman Mick Wozniak 2005 OL 30 10.6 6-17 8 NR 26.7 1.2 1.5 2.1 2.0 Baseline .001 Antipsychotic-mood-stabilizer combination therapy N 3 Ì1 73 Quetiapine divalproex 15 DelBello Schwiers 2002 DBRC 15 14.3 12-18 6 4.Z 46.7 432 DVPX 104 pg mL 4.2 3.2 VPA 2.5 2.1 kg NS Risperidone divalproex zz 20 Pavuluri 2004 OLR 20 12.1 5-18 24 20 0.0 0.7 0.7 6.0 3.8 Baseline NR Risperidone lithium zz 38 Pavuluri 2004 OLR 17 12.1 5-18 24 12.2C 58.8 0.7 0.7 6.8 4.2 Baseline NR Pavuluri 2006 OL 21 10.5 4-17 44 19.1J NR 1.0 0.5 Li 775 400 0.87 mEq L 3.7J CDC growth curve Li 3.3 kg NS 0.34 Note. Adapted from Correll 2007 . Copyright 2007 by the American Academy of Child and Adolescent Psychiatry. Adapted by permission. CR chart review DBRC double-blind randomized controlled N A not applicable NR not reported NS not significant OL open label OLR open label randomized VP A valproate DVPX divalproex Li lithium CDC Centers for Disease Control. Patient n may be larger in a given study but only patients on index medication with data on weight gain are included. In ascending order of trial duration. Calculated. Individual data for lithium risperidone group provided by the author Pavuluri personal communication July 11 2006 . Weight Gain and Metabolic Abnormalities 375 different from divalproex treatment alone 3.6 6.0 . In a chart review study of 19 children and adolescents mean age 10.8 years 24 weeks of quetiapine treatment were associated with a mean increase in BMI of 0.8 kg m2 which was not significant compared with baseline DelBello Schwiers et al. 2002 . Risperidone In an 8-week open-label trial of 16 preschoolers mean age 5.3 years risperidone treatment was associated with a weight gain of 2.2 0.4 kg or 10.1 6.1 baseline body weight Biederman Mick Hammerness et al. 2005 . It was not reported whether or not .