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BASIC AND CLINICAL DERMATOLOGY - PART 10

Dermoelectroporation là một phương pháp điều trị cho phép hấp thu các chất hoạt động (thông thường họ là những giải pháp thuốc ion) sử dụng thiết bị tạo ra xung điện cho phép mở cửa di động "điện" và thúc đẩy việc thông qua các chất thông qua các lớp biểu bì. Năm 1970, một nhóm các bác sĩ da liễu | 18 The Role of Dermoelectroporation Pier Antonio Bacci University of Siena Siena Italy and Cosmetic Pathologies Center Arezzo Italy INTRODUCTION Dermoelectroporation is a treatment method that enables absorption of active substances normally they are ionic drug solutions using equipment that generate electric pulses allowing the opening of cellular electric gates and promoting the passage of substances through the epidermis. In 1970 a group of American dermatologists discovered that by applying an intense electrical impulse for a short time at an adequate wave length a change in polarization of the cellular membrane occurred which could be used to promote a kind of cellular pulsation. In fact after the initial pulse the polarity is slowly reversed avoiding electrolysis and this opens intercellular channels through which substances can pass. Once they are formed these channels stay open for a relatively long time several seconds. This method was named electroporation and was used with special techniques in the transdermic treatment of melanomas. Electroporation with high voltage is the only system that can introduce substances of high molecular weight transdermally. Over 4000 published scientific reports demonstrate the actions and possible uses of the method 9 . Despite the very similar name dermoelectroporation is different because this new method works with lower voltages in comparison to electroporation. In the apparatus used for medical and aesthetic purposes Transderm Ionto by Mattioli Engineering Florence Italy dermoelectroporation treatment is applied by a discharge given by an electric inductor charged at a controlled current value and then discharged with a typical kind of reversible exponential voltage wave. Why does the new method work well only after dermabrasion of the horny layer The answer can be that the high voltage in classical electroporation produces only partly poration of the horny layer and partly poration of the dermis with the residual .