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Báo cáo y học: "Prediabetes and prehypertension in disease free obese adults correlate with an exacerbated systemic proinflammatory milieu."

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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Prediabetes and prehypertension in disease free obese adults correlate with an exacerbated systemic proinflammatory milieu. | Gupta and Johnson Journal of Inflammation 2010 7 36 http www.journal-inflammation.eom content 7 1 36 JOURNAL OF INFLAMMATION RESEARCH Open Access Prediabetes and prehypertension in disease free obese adults correlate with an exacerbated systemic proinflammatory milieu Alok K Gupta William D Johnson Abstract Background Obesity is a pro-inflammatory state frequently associated with widespread metabolic alterations that include insulin resistance and deregulation of blood pressure BP . This cascade of events in some measure explains the susceptibility of obese adults for co-morbid conditions like diabetes mellitus and hypertension. Hypothesis We hypothesized that an elevated systemic proinflammatory burden correlates with dysglycemia and deregulated blood pressure. Methods We analyzed the screening anthropometric and laboratory measures from healthy disease free obese adults n 35 women W 27 men M 8 in a weight loss study. Results Healthy obese normoglycemic fasting serum glucose FSG 100 mg dL women and men compared with healthy obese with prediabetes FSG 100-125 mg dL had no significant differences for age Mean SD 52 12 vs. 56 9 y weight 95 11 vs. 99 13 kg or waist circumference 108 10 vs. 108 11 cm . Normoglycemic group n 24 W 19 M 5 had normal FSG 92 4 mg dL HbA1c 5.4 0.3 BP 118 75 mm Hg but had elevated high sensitivity C-reactive protein hs CRP 3.7 3 mg L and fibrinogen 472 76 mg dL. The group with prediabetes n 11 W 8 M 3 with significantly higher FSG 106 3 mg dL p 0.0001 HbA1c 5.9 0.5 p 0.002 had prehypertension BP 127 80 mm Hg and significantly higher hs CRP 16.9 9 mg p 0.0001 and fibrinogen 599 95 mg dL p 0.0002 . Conclusions In otherwise healthy disease free obese adults a higher degree of systemic inflammation is associated with prediabetes and prehypertension. Introduction Overweight and obese adults in comparison to their non-obese counterparts have a greater susceptibility for subsequently developing diabetes mellitus and or hypertension 1 2 . Obesity is

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