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Báo cáo y học: " Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease"

Tham khảo luận văn - đề án 'báo cáo y học: " genetic polymorphism of ace and the angiotensin ii type1 receptor genes in children with chronic kidney disease"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Elshamaa et al. Journal of Inflammation 2011 8 20 http www.journal-inflammation.eom content 8 1 20 JOURNAL OF INFLAMMATION RESEARCH Open Access Genetic polymorphism of ACE and the angiotensin II typel receptor genes in children with chronic kidney disease 1 2 2 1 3 3 Manal F Elshamaa Samar M Sabry Hafez M Bazaraa Hala M Koura Eman A Elghoroury Nagwa A Kantoush Eman H Thabet3 and Dalia A Abd-El Haleem3 Abstract Aim and Methods We investigated the association between polymorphisms of the angiotensin converting enzyme-1 ACE-1 and angiotensin II type one receptor AT1RA1166C genes and the causation of renal disease in 76 advanced chronic kidney disease CKD pediatric patients undergoing maintenance hemodialysis MHD or conservative treatment CT . Serum ACE activity and creatine kinase-MB fraction CK-MB were measured in all groups. Left ventricular mass index LVMI was calculated according to echocardiographic measurements. Seventy healthy controls were also genotyped. Results The differences of D allele and DI genotype of ACE were found significant between MHD group and the controls p 0.0001 . ACE-activity and LVMI were higher in MHD while CK-MB was higher in CT patients than in all other groups. The combined genotype DD v s ID II comparison validated that DD genotype was a high risk genotype for hypertension . 89 of the DD CKD patients were found hypertensive in comparison to 61 of patients of non DD genotype p 0.02 . The MHD group showed an increased frequency of the C allele and CC genotype of the AT1RA1166C polymorphism P 0.0001 . On multiple linear regression analysis C-allele was independently associated with hypertension P 0.04 . Conclusion ACE DD and AT1R A C genotypes implicated possible roles in the hypertensive state and in renal damage among children with ESRD. This result might be useful in planning therapeutic strategies for individual patients. Keywords angiotensin-converting enzyme angiotensin II type one receptor DNA polymorphisms end-stage renal disease .