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Báo cáo khoa hoc:" On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors | Journal of Negative Results in BioMedicine BioMed Central Research Open Access On the genetic involvement of apoptosis-related genes in Crohn s disease as revealed by an extended association screen using 245 markers no evidence for new predisposing factors Sonja EN Wagenleiter1 Peter Jagiello2 Denis A Akkad1 Larissa Arning1 Thomas Griga3 Wolfram Klein1 and Jorg T Epplen 1 Address Department of Human Genetics Ruhr-University Bochum Germany 2Institute for Clinical Molecular Biology University Schleswig-Holstein Kiel Germany and 3Department of Gastroenterology University Hospital Bergmannsheil Bochum Germany Email Sonja EN Wagenleiter - sunnie1@gmx.de Peter Jagiello - pjag@gmx.de Denis A Akkad - amer.akkad@rub.de Larissa Arning - larissa.arning@rub.de Thomas Griga - thomas.griga@kk-dortmund.de Wolfram Klein - wolfram.klein@rub.de JorgT Epplen - joerg.t.epplen@rub.de Corresponding author Published 30 November 2005 Received 07 July 2005 Accepted 30 November 2005 Journal of Negative Results in BioMedicine 2005 4 8 doi l0.ll86 l 477-5751-4-8 r This article is available from http www.jnrbm.com content 4 1 8 2005 Wagenleiter et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Crohn s disease CD presents as an inflammatory barrier disease with characteristic destructive processes in the intestinal wall. Although the pathomechanisms of CD are still not exactly understood there is evidence that in addition to e.g. bacterial colonisation genetic predisposition contributes to the development of CD. In order to search for predisposing genetic factors we scrutinised 245 microsatellite markers in a population-based linkage mapping study. These microsatellites cover gene loci the encoded protein of which take part in the .