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Báo cáo y học: "Early Reversal of experimental colitis disease activity in mice following administration of an adenoviral IL-10 vector"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early Reversal of experimental colitis disease activity in mice following administration of an adenoviral IL-10 vector. | Journal of Inflammation BioMed Central Research Open Access Reversal of experimental colitis disease activity in mice following administration of an adenoviral IL-10 vector Makoto Sasaki1 J Michael Mathis2 Merilyn H Jennings1 Paul Jordan3 Yuping Wang4 Tomoaki Ando1 Takashi Joh5 and J Steven Alexander 1 Address Department of Molecular and Cellular Physiology LSU Health Sciences Center Shreveport LA 71130-3932 USA 2Department of Cell Biology and Anatomy LSU Health Sciences Center Shreveport LA 71130-3932 USA 3Department of Gastroenterology LSU Health Sciences Center Shreveport LA 71130-39322 USA 4Department of Obstetrics and Gynecology LSU Health Sciences Center Shreveport LA 7113039322 USA and 5Department of Internal Medicine and Bioregulation Nagoya City University Graduate School of Medical Sciences Nagoya Japan Email Makoto Sasaki - msasaki@lsuhsc.edu J Michael Mathis - jmathi@lsuhsc.edu Merilyn H Jennings - mjenni@lsuhsc.edu Paul Jordan - pjorda1@lsuhsc.edu Yuping Wang - ywang1@lsuhsc.edu Tomoaki Ando - tando@lsuhsc.edu Takashi Joh - jalexa@lsuhsc.edu J Steven Alexander - jalexa@lsuhsc.edu Corresponding author Published 31 October 2005 Received 13 June 2005 Journal of Inflammation 2005 2 13 doi 10.1186 1476-9255-2-13 Accepted 31 October 2005 This article is available from http www.journal-inflammation.cOm content 2 1 13 2005 Sasaki et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Genetic deficiency in the expression of interleukin-10 IL-10 is associated with the onset and progression of experimental inflammatory bowel disease IBD . The clinical significance of IL-10 expression is supported by studies showing that immune-augmentation of IL-10 prevents inflammation and mucosal damage in animal models of .