Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Early Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts"

Không đóng trình duyệt đến khi xuất hiện nút TẢI XUỐNG

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts. | Journal of Inflammation BioMed Central Research Open Access Nurrl dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts Mark R Davies Christine J Harding Stephanie Raines Kurt Tolley Andrew E Parker Mark Downey-Jones and Maurice RC Needham Address Respiratory and Inflammation Research Department AstraZeneca Mereside Alderley Park Macclesfield Cheshire SK10 4TG UK Email Mark R Davies - mark.r.davies@astrazeneca.com Christine J Harding - christine.harding@astrazeneca.com Stephanie Raines - stephanie.raines@astrazeneca.com Kurt Tolley - kurt.tolley@astrazeneca.com Andrew E Parker - andrew.parker@astrazeneca.com Mark Downey-Jones - mark.downey-jones@astrazeneca.com Maurice RC Needham - maurice.needham@astrazeneca.com Corresponding author Published 25 November 2005 Received 03 August 2005 Journal of Inflammation 2005 2 15 doi 10.1186 1476-9255-2-15 Accepted 25 November 2005 This article is available from http www.journal-inflammation.com content 2 1 15 2005 Davies et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Nurrl is an orphan member of the nuclear receptor superfamily these orphan receptors are a group for which a ligand has yet to be identified. Nurr1 has been shown to regulate the expression of a small number of genes as a monomeric constitutively active receptor. These Nurr1 regulated genes are primarily associated with dopamine cell maturation and survival. However previous reports have shown an increased expression of Nurr1 in the synovium of patients with rheumatoid arthritis RA suggesting a pro-inflammatory role for Nurr1 in RA. In this study we investigate the potential pro-inflammatory role of Nurr1 by monitoring Nurr1 dependent gene expression in an .

TÀI LIỆU LIÊN QUAN

Báo cáo y học: "Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading"

Báo cáo y học: " Pathogenesis of rheumatoid arthritis: how early is early"

Báo cáo y học: "Atherogenic lipid profile is a feature characteristic of patients with early rheumatoid arthritis: effect of early treatment – a prospective, controlled study"

Báo cáo y học: "Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis: the 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial"

Báo cáo y học: "A randomised controlled comparison of early post-pyloric versus early gastric feeding to meet nutritional targets in ventilated intensive care patients"

Báo cáo y học: "Further benefits by early start of HIV treatment in low income countries: Survival estimates of early versus deferred antiretroviral therapy"

báo cáo khoa học: " Early exit: Estimating and explaining early exit from drug treatment"

Báo cáo y học: "Voxel-based structural magnetic resonance imaging (MRI) study of patients with early onset schizophrenia"

Báo cáo y học: "Increased frequency of metabolic syndrome among Vietnamese women with early rheumatoid arthritis: a cross-sectional study"

Báo cáo y học: "Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta"
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.