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Báo cáo y học: "Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E2. | Journal of Inflammation o BioMed Central Research Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens and impact of exogenous prostaglandin E2 Aida Herrerias1 Rosa Torres1 2 3 Mariona Serra1 Alberto Marco4 Laura Pujols2 3 César Picado2 3 and Fernando de Mora 1 Address Department of Pharmacology Universitat Autònoma de Barcelona Barcelona Spain 2Department of Pneumology and Respiratory Allergy Hospital Clinic IDIBAPS Universitat de Barcelona Spain 3CIBER Centro de Investigación Biomédica en Red de Enfermedades Respiratorias Spain and 4Department of Animal Pathology Universitat Autònoma de Barcelona Barcelona Spain Email Aida Herrerias - aida.herrerias@uab.cat Rosa Torres - rosa.torres@uab.cat Mariona Serra - mariona.serra@uab.cat Alberto Marco - alberto.marco@uab.cat Laura Pujols - lpujols@clinic.ub.es César Picado - cpicado@uab.edu Fernando de Mora - fernando.demora@uab.cat Corresponding author Published 30 October 2009 Received 4 May 2009 Journal of Inflammation 2009 6 30 doi 10.1186 1476-9255-6-30 Accepted 30 October 2009 This article is available from http www.journal-inflammation.com content 6 1 30 2009 Herrerias et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Prostaglandin E2 PGE2 experimentally administered to asthma patients or assayed in murine models improves allergen-driven airway inflammation. The mechanisms are unknown but fluctuations of the endogenous cyclooxygenase COX -2 prostaglandin E prostanoid EP receptor pathway activity likely contribute to the clinical outcome. We analyzed the activity of the pathway in mice sensitized to aeroallergens and then studied its modulation under exogenous PGE2. Methods Mice .