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Báo cáo y học: "Levamizole enhances immune responsiveness to intra-dermal and intra-muscular hepatitis B vaccination in chronic hemodialysis patients"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Levamizole enhances immune responsiveness to intra-dermal and intra-muscular hepatitis B vaccination in chronic hemodialysis patients. | Journal of Immune Based Therapies and Vaccines BioMed Central Original research Levamizole enhances immune responsiveness to intra-dermal and intra-muscular hepatitis B vaccination in chronic hemodialysis patients Hassan Argani 1 2 and Ebrahim Akhtarishojaie3 Open Access Address Division of nephrology Modarres hospital Shahid beheshti university of medical sciences Tehran Iran 2Drug applied research center Tabriz university of medical sciences Tabriz Iran and 3Drug applied research center Tabriz university of medical sciences Tabriz Iran Email Hassan Argani - hassanargani@hotmail.com Ebrahim Akhtarishojaie - akhtari20@yahoo.com Corresponding author Published 30 May 2006 Received 25 November 2005 Journal of Immune Based Therapies and Vaccines 2006 4 3 doi l0.ll86 l 476-8518-4-3 Accepted 30 May 2006 This article is available from http www.jibtherapies.cOm content 4 1 3 2006 Hassan and Ebrahim licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Hemodialysis patient are at high risk for hepatitis B virus HBV infection. Although preventive vaccination is done routinely the response to vaccination is low in this patient population. The aim of this study was to evaluate the effect of Levamizol an enhancer of the immune responsiveness on different routs of vaccination i.e. intradermal ID versus intramuscular IM in stable chronic hemodialysis patients. Materials and methods Forty four chronic heamodialyses patient were divided into four equal groups. The first group was received 40 pg HB vaccine intramuscularly. The second group was received 20 pg HB vaccine intradermally. The third and the fourth group received 20 pg vaccine IM or