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Báo cáo y học: "A fatal case of bupropion (Zyban) hepatotoxicity with autoimmune features: Case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A fatal case of bupropion (Zyban) hepatotoxicity with autoimmune features: Case report. | Journal of Medical Case Reports BioMed Central Case report Open Access A fatal case of bupropion Zyban hepatotoxicity with autoimmune features Case report Fawwaz Humayun1 Thomas M Shehab1 2 5 Joseph A Tworek3 and Robert J Fontana 4 Address Department of Internal Medicine St. Joseph Mercy Health System Ypsilanti Michigan 48197 USA 2Section of Gastroenterology St. Joseph Mercy Health System Ypsilanti Michigan 48197 USA 3Department of Pathology St. Joseph Mercy Health System Ypsilanti Michigan 48197 USA 4Department of Internal Medicine Division of Gastroenterology University of Michigan Medical Center Ann Arbor Michigan 48109 USA and 5Huron Gastro Center for Digestive Care Ypsilanti Michigan 48197 USA Email Fawwaz Humayun - humayuf@hotmail.com Thomas M Shehab - shehabt@trinity-health.org Joseph ATworek - jtworek@yahoo.com Robert J Fontana - rfontana@med.umich.edu Corresponding author Published 18 September 2007 Received 20 April 2007 Journal of Medical Case Reports 2007 1 88 doi 10.1186 1752-1947-1-88 Accepted 18 September 2007 This article is available from http www.jmedicalcasereports.cOm content 1 1 88 2007 Humayun et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Bupropion is approved for the treatment of mood disorders and as an adjuvant medication for smoking cessation. Bupropion is generally well tolerated and considered safe. Two randomized controlled trials of bupropion therapy for smoking cessation did not report any hepatic adverse events. However there are three reports of severe but non-fatal bupropion hepatotoxicity published in the literature. Case Presentation We present the case of a 55-year old man who presented with jaundice and severe hepatic injury approximately 6 months after .