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Báo cáo y học: "Duodenal enteroglucagonoma revealed by differential comparison of serum and tissue glucagon reactivity with Siemens' Double Glucagon Antibody and DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Duodenal enteroglucagonoma revealed by differential comparison of serum and tissue glucagon reactivity with Siemens' Double Glucagon Antibody and DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon: a case report. | Vanderlan et al. Journal of Medical Case Reports 2010 4 178 http www.jmedicalcasereports.eom content 4 1 178 jA JOURNALOF.MEDICAL CASE REPORTS CASE REPORT Open Access Duodenal enteroglucagonoma revealed by differential comparison of serum and tissue glucagon reactivity with Siemens Double Glucagon Antibody and DakoCytomation s Polyclonal Rabbit Anti-Human Glucagon a case report Wesley B Vanderlan 1 Ziying Zhang2 and Marwan S Abouljoud1 Abstract Introduction This case report demonstrates that the differential immunohistochemical reactivities of Siemens Double Antibody Glucagon compared to DakoCytomation s Polyclonal Rabbit Anti-Human Glucagon allow for pathologic distinction of enteral versus pancreatic glucagonoma. Case presentation A 64-year-old Caucasian man was diagnosed with a duodenal enteroglucagonoma following presentation with obstructive jaundice. He had a low serum glucagon level using Siemens Double Antibody Glucagon a clinical syndrome consistent with glucagon hypersecretion. A periampullary mass biopsy proved to be a neuroendocrine tumor with positive immunohistochemical reactivity to DakoCytomation s Polyclonal Rabbit AntiHuman Glucagon. Conclusions Differential comparison of the immunohistochemical reactivities of Siemens Double Antibody Glucagon and DakoCytomation s Polyclonal Rabbit Anti-Human Glucagon discerns enteroglucagon from pancreatic glucagon. Introduction Pancreatic glucagonomas are rare neuroendocrine tumors with an estimated incidence of approximately 1 in 20 million 1 . Duodenal glucagonomas are reported but are even rarer with an unknown true incidence 2 . Necrotizing migratory erythema NME glucose intolerance weight loss and anemia form a presenting constellation known as the glucagonoma syndrome. Patients most commonly present in the sixth decade of life with an even gender distribution. Tumors usually present larger than 4 cm and are commonly associated with metastasis in over 50 of patients 3 4 . Neuroendocrine tumors are .