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Báo cáo y học: "Post-transplant lymphoproliferative disorder involving the ovary as an initial manifestation: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Post-transplant lymphoproliferative disorder involving the ovary as an initial manifestation: a case report. | Inoue et al. Journal of Medical Case Reports 2010 4 184 http www.jmedicalcasereports.eom content 4 1 184 Ws JOURNALOF.MEDICAL CASE REPORTS OCASE REPORT Open Access Post-transplant lymphoproliferative disorder involving the ovary as an initial manifestation a case report Takamitsu Inoue Shigeru Satoh Mitsuru Saito Yohei Horikawa Norihiko Tsuchiya and Tomonori Habuchi Abstract Introduction Because the normal ovary is assumed to be devoid of lymphoid tissue it is unusual for it to be an initial manifestation of malignant lymphoma. This case is the first report to our knowledge of post-transplant lymphoproliferative disorder involving the ovary as an initial manifestation. Case presentation Twenty-nine weeks after a living renal transplantation a 38-year-old Japanese female whose ethnic origin was Asian presented with abdominal pain and a chronic high fever. Computed tomography revealed a right ovarian tumor and liver metastases. The patient underwent oophrectomy based on the clinical diagnosis of liver metastasis from the primary ovarian tumor. The pathological diagnosis was Epstein-Barr Virus-associated posttransplant lymphoproliferative disorder. While ovarian malignant lymphoma has a poor prognosis complete remission of liver involvement in this case was achieved only with a reduction of immunosuppressants. Conclusion Clinicians should remember that malignant lymphoma could initially involve the ovary especially if the patient is immunosuppressed after transplantation therapy. Introduction Post-transplant lymphoproliferative disorder PTLD is a type of malignant lymphoma which is a potentially lifethreatening complication that occurs in approximately 1.7 to 3.5 of solid-organ transplantation recipients 1 . While ovarian involvement of malignant lymphoma usually occurs late in the course of a disseminated disease it is unusual to find an ovarian mass as an initial manifestation 2 . Patients with ovarian malignant lymphoma have a poor prognosis 2 . We report an .