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báo cáo khoa học: " Gut microbiome-host interactions in health and disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Gut microbiome-host interactions in health and disease | Kinross et al. Genome Medicine 2011 3 14 http genomemedicine.eom content 3 3 14 w Genome Medicine REVIEW L_ Gut microbiome-host interactions in health and disease James M Kinross1 Ara W Darzi1 and Jeremy K Nicholson 2 Abstract The gut microbiome is the term given to describe the vast collection of symbiotic microorganisms in the human gastrointestinal system and their collective interacting genomes. Recent studies have suggested that the gut microbiome performs numerous important biochemical functions for the host and disorders of the microbiome are associated with many and diverse human disease processes. Systems biology approaches based on next generation omics technologies are now able to describe the gut microbiome at a detailed genetic and functional transcriptomic proteomic and metabolic level providing new insights into the importance of the gut microbiome in human health and they are able to map microbiome variability between species individuals and populations. This has established the importance of the gut microbiome in the disease pathogenesis for numerous systemic disease states such as obesity and cardiovascular disease and in intestinal conditions such as inflammatory bowel disease. Thus understanding microbiome activity is essential to the development of future personalized strategies of healthcare as well as potentially providing new targets for drug development. Here we review recent metagenomic and metabonomic approaches that have enabled advances in understanding gut microbiome activity in relation to human health and gut microbial modulation for the treatment of disease. We also describe possible avenues of research in this rapidly growing field with respect to future personalized healthcare strategies. Correspondence j.nicholson@imperial.ac.uk 2Section of Bimolecular Medicine Department of Surgery and Cancer Faculty of Medicine Imperial College London The Sir Alexander Fleming Building South Kensington London SW7 2AZ UK Full list of .