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Báo cáo y học: " Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic: a prospective cohort analysis"

Tham khảo luận văn - đề án 'báo cáo y học: " borna disease virus (bdv) circulating immunocomplex positivity in addicted patients in the czech republic: a prospective cohort analysis"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Rackova et al. BMC Psychiatry 2010 10 70 http www.biomedcentral.com 1471-244X 10 70 BMC Psychiatry RESEARCH ARTICLE Open Access Borna disease virus BDV circulating immunocomplex positivity in addicted patients in the Czech Republic a prospective cohort analysis Sylva Rackova1 Lubos Janu1 Hana Kabickova2 Abstract Background Borna disease virus BDV is an RNA virus belonging to the family Bornaviridae. Borna disease virus is a neurotropic virus that causes changes in mood behaviour and cognition. BDV causes persistent infection of the central nervous system. Immune changes lead to activation of infection. Alcohol and drug dependence are associated with immune impairment. Methods We examined the seropositivity of BDV circulating immunocomplexes CIC in patients with alcohol and drug dependence and healthy individuals blood donors . We examined 41 addicted patients for the presence of BDV CIC in the serum by ELISA at the beginning of detoxification and after eight weeks of abstinence. This is the first such study performed in patients with alcohol and drug dependence. Results BDV CIC positivity was detected in 36.59 of addicted patients on day 0 and in 42.86 on day 56. The control group was 37.3 positive. However we did not detect higher BDV CIC positivity in addicted patients in comparison with blood donors p 0.179 . The significantly higher level of BDV CIC was associated with lower levels of GGT gamma glutamyl transferase p 0.027 and approached statistical significance with the lower age of addicted patients p 0.064 . We did not find any association between BDV CIC positivity and other anamnestic and demographic characteristics. Conclusions In our study addicted patients did not have significantly higher levels of BDV CIC than the control group. The highest levels of BDV CIC were detected in patients with lower levels of GGT and a lower age. Trial registration This study was approved by the ethical committee of the University Hospital Medical Faculty of Charles .