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Báo cáo y học: " The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder | Lonsdorf et al. BMC Psychiatry 2010 10 99 http www.biomedcentral.com 1471-244X 10 99 BMC Psychiatry RESEARCH ARTICLE Open Access The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder I I u . s D I L . I- J A1 3 4 5 7C h ri rfi I Di I r I 2 I D f m 2 f r r A A I f v r r r 2 6 A r r i A m 1 4 5 I I 11- I I L . .r-J - .4- - VI 2 lina B LonsdorT Christian ruck Jan Bergstrom Gerhard Andersson Arne unman Nils LindeTors Martin Schalling3 Abstract Background Cognitive behavioral therapy CBT represents a learning process leading to symptom relief and resulting in long-term changes in behavior. CBT Tor panic disorder is based on exposure and exposure-based processes can be studied in the laboratory as extinction oT experimentally acquired Tear responses. We have recently demonstrated that the ability to extinguish learned Tear responses is associated with a functional genetic polymorphism COMTval158met in the COMT gene and this study was aimed at transferring the experimental results on the COMTval158met polymorphism on extinction into a clinical setting. Methods We tested a possible effect oTthe COMTval158met polymorphism on the efficacy oT CBT in particular exposure-based treatment modules in a sample oT 69 panic disorder patients. Results We present evidence that panic patients with the COMTval158met met met genotype may proTit less Trom exposure-based CBT treatment methods as compared to patients carrying at least one val-allele. No association was Tound with the 5-HTTLPR rs25531 genotypes which is presented as additional material. Conclusions We were thus able to transTer Tindings on the effect oT the COMTval158met polymorphism Trom an experimental extinction study obtained using healthy subjects to a clinical setting. Furthermore patients carrying a COMT val-allele tend to report more anxiety and more depression symptoms as compared to those with the met met genotype. Limitations oT the .