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Báo cáo y học: "Insular cortex involvement in declarative memory deficits in patients with post-traumatic stress disorder"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Insular cortex involvement in declarative memory deficits in patients with post-traumatic stress disorder | BMC Psychiatry BioMed Central Research article Insular cortex involvement in declarative memory deficits in patients with post-traumatic stress disorder Shulin Chen 1 2 3 Lingjiang Li3 BaihuaXu2 and Jun Liu3 Address Department of Medical Psychology the Seventh Hospital of Hangzhou Zhejiang PR China 2Department of Psychology Zhejiang University Hangzhou Zhejiang PR China and 3Mental Health Institute the Second Xiangya Hospital Central South University Changsha Hunan PR China Email Shulin Chen - shulinchen1990@gmail.com Lingjiang Li-lilj2920@163.com BaihuaXu-xubaihua501@126.com Jun Liu - lj75832003@yahoo.com.cn Corresponding author Open Access Published 18 June 2009 Received 31 August 2008 BMC Psychiatry 2009 9 39 doi l0.ll86 l47l-244X-9-39 Accepted 18 June 2009 This article is available from http www.biomedcentral.cOm l47l-244X 9 39 2009 Chen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Neuroimaging studies have proved that hippocampus relate to the deficient of memory in patients with post-traumatic stress disorder PTSD . Many studies in healthy subjects also shown that insular cortex IC be involved in the declarative memory. This study was designed to investigate whether insular cortex is involved in declarative memory deficits in patients with PTSD. Methods Twelve subjects with PTSD and 12 subjects without PTSD victims underwent functional magnetic resonance imaging and magnetic resonance imaging. All subjects performed encoding and retrieval memory tasks during the fMRI session. Voxel-based morphometry method was used to analyze gray-matter volume and the Statistical Parametric Mapping SPM2 was used to analyze