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Báo cáo y học: " Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report | JOURNAL OF MEDICAL Sr CASE REPORTS Open Access Case report Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation a case report Gerhard Behre Sebastian Theurich Maximilian Christopeit and Thomas Weber1 Address Department of Internal Medicine IV Oncology and Haematology Martin-Luther-University Halle-Wittenberg Ernst-Grube-Strasse 06097 Halle Germany Email GB - gerhard.behre@medizin.uni-halle.de ST - sebastian.theurich@medizin.uni-halle.de MC - maximilian.christopeit@medizin.uni-halle.de TW - thomas.weber@medizin.uni-halle.de Corresponding author fEqual contribution Received 25 April 2008 Accepted 24 February 2009 Published 10 March 2009 Journal of Medical Case Reports 2009 3 6164 doi 10.4076 1752-1947-3-6164 This article is available from http jmedicalcasereports.com jmedicalcasereports article view 6164 2009 Behre et al licensee Cases Network Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 3.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction We report a case of sinusoidal obstruction syndrome a typical and life-threatening complication after allogeneic stem-cell transplantation successfully treated with defibrotide despite massive multiple organ failure. Case presentation A 64-year-old Caucasian woman underwent allogeneic peripheral blood stemcell transplantation from her human leukocyte antigen-identical sister against aggressive lympho-plasmocytoid immunocytoma. Seven days later the patient developed severe sinusoidal obstruction syndrome according to the modified Seattle criteria. We initiated treatment with defibrotide. Despite early treatment multiple organ failure with kidney failure requiring dialysis and ventilator-dependent lung failure aggravated the clinical course. .