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báo cáo khoa học: " 3-D reconstruction of a human fetus with combined holoprosencephaly and cyclopia"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: 3-D reconstruction of a human fetus with combined holoprosencephaly and cyclopia | Head Face Medicine BioMed Central Research 3-D reconstruction of a human fetus with combined holoprosencephaly and cyclopia Wolfgang H Arnold - and Veronika MeiselbacM Address Department of Anatomy Faculty of Dental Medicine University of Witten Herdecke Alfred Herrhausenstrasse 50 58448 Witten Germany Email Wolfgang H Arnold - wolfgang.arnold@uni-wh.de Veronika Meiselbach - veronikam11@hotmail.com Corresponding author tEqual contributors Open Access Published 29 June 2009 Received 9 March 2009 Head Face Medicine 2009 5 14 doi 10.1186 1746-160X-5-14 Accepted 29 June 2009 This article is available from http www.head-face-med.cOm content 5 1 14 2009 Arnold and Meiselbach licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background The purpose of this study was to examine a human fetus with combined holoprosencephaly and cyclopia by means of histology and 3-D reconstruction to determine the internal structure and extent of the malformation. Methods The head from a human fetus at 20 weeks gestation and a diagnosis of holoprosencephaly and cyclopia was investigated histologically and three-dimensionally reconstructed with CAD techniques. The cranial bones blood vessels nerves eye and brain anlagen were reconstructed. Results The 3-D reconstruction revealed both severe malformation and absence of the facial midline bones above the maxilla and a malformation of the maxilla and sphenoid bone. The mandible posterior cranial bones cranial nerves and blood vessels were normal. A synophthalmic eye with two lenses was found. The prosencephalon was a single small protrusion above the diencephalon. No nasal cavity was present. Above the single eye a .