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Báo cáo y học: " Post-transcriptional control by bacteriophage T4: mRNA decay and inhibition of translation initiation"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Post-transcriptional control by bacteriophage T4: mRNA decay and inhibition of translation initiation | Uzan and Miller Virology Journal 2010 7 360 http www.virologyj.eom content 7 1 360 J VIROLOGY JOURNAL REVIEW Open Access Post-transcriptional control by bacteriophage T4 mRNA decay and inhibition of translation initiation Marc Uzan1 Eric S Miller2 Abstract Over 50 years of biological research with bacteriophage T4 includes notable discoveries in post-transcriptional control including the genetic code mRNA and tRNA the very foundations of molecular biology. In this review we compile the past 10-15 year literature on RNA-protein interactions with T4 and some of its related phages with particular focus on advances in mRNA decay and processing and on translational repression. Binding of T4 proteins RegB RegA gp32 and gp43 to their cognate target RNAs has been characterized. For several of these further study is needed for an atomic-level perspective where resolved structures of RNA-protein complexes are awaiting investigation. Other features of post-transcriptional control are also summarized. These include RNA structure at translation initiation regions that either inhibit or promote translation initiation programmed translational bypassing where T4 orchestrates ribosome bypass of a 50 nucleotide mRNA sequence phage exclusion systems that involve T4-mediated activation of a latent endoribonuclease PrrC and cofactor-assisted activation of EF-Tu proteolysis Gol-Lit and potentially important findings on ADP-ribosylation by Alt and Mod enzymes of ribosome-associated proteins that might broadly impact protein synthesis in the infected cell. Many of these problems can continue to be addressed with T4 whereas the growing database of T4-related phage genome sequences provides new resources and potentially new phage-host systems to extend the work into a broader biological evolutionary context. Introduction The temporal ordering of bacteriophage T4 development is assured in great part by the cascade activation of three different classes of promoters see 1 2 in this series . .