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Báo cáo y học: " Serum albumin and mortality risk in a hyperendemic area of HCV infection in Japan"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Serum albumin and mortality risk in a hyperendemic area of HCV infection in Japan | Nagao and Sata Virology Journal 2010 7 375 http www.virologyj.eom content 7 1 375 J VIROLOGY JOURNAL RESEARCH Open Access Serum albumin and mortality risk in a hyperendemic area of HCV infection in Japan Yumiko Nagao1 Michio Sata1 2t Abstract Background Hypoalbuminemia has been shown to be associated with increased mortality. We reported a mass screening in 1990 of X town in Japan which demonstrated a high prevalence of hepatitis C virus HCV infection. This follow-up study determined through a period of 12 years whether serum albumin levels impact on the life prognosis of the residents of X town. Results Of the 509 subjects 69 had died and 55 had moved to other regions by 2002. Therefore we analyzed 454 people for whom we could confirm life and death between 1990 and 2002. Albumin levels were assigned to two groups low 4.0 g L group A and normal 4.0 g L group B . Of the 454 subjects analyzed 25 were in group A and 429 in group B and the mortality was 68.0 17 25 cases P 0.00001 vs. group B and 12.1 52 429 respectively. Mortality from hepatocellular carcinoma HCC was 66.7 in group A 6 9 cases P 0.01 vs. group B and 15.8 3 19 in group B. According to multivariate analysis five factors - 50 years or older low albumin level 4.0 g L abnormal AST level history of smoking and absence of alcohol consumption - were associated with death. The adjusted odds ratios for these five factors were 20.65 10.79 2.58 2.24 and 2.08 respectively and each was statistically significant. Conclusions We show that the serum albumin level is an independent risk factor for mortality from all causes in the residents of X town and an important prognostic indicator. Improvement of hypoalbuminaemia should be considered for improvement of prognosis. Background Hypoalbuminemia can be caused by various conditions including nephrotic syndrome 1 2 heart failure 3 liver disease 4 5 and malnutrition 6 . Most cases of hypoalbuminemia among hospitalized patients are caused by acute and chronic inflammatory