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Báo cáo y học: " Comparative genomic analysis of bacteriophages specific to the channel catfish pathogen Edwardsiella ictaluri"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Comparative genomic analysis of bacteriophages specific to the channel catfish pathogen Edwardsiella ictaluri | VIROLOGY JOURNAL eiDWF eiMSLS B Enterobacteria phage SSL-2009a GC content Comparative genomic analysis of bacteriophages specific to the channel catfish pathogen Edwardsiella ictaluri Carrias et al. 2 BioMed Central Carrias et al. Virology Journal 2011 8 6 http www.virologyj.com content 8 1 6 7 January 2011 Carrias et al. Virology Journal 2011 8 6 http www.virologyj.eom content 8 1 6 RESEARCH J VIROLOGY JOURNAL Open Access Comparative genomic analysis of bacteriophages specific to the channel catfish pathogen Edwardsiella ictaluri AHdl s rri s c1 Timrsfhv I lA di h2 CofWo s A i IHHidCdr2 A It laarl4 offoi . Q Tcurhi me1 r lsrl p I ildc5 Abel Camas Timothy J Welch Geoiney C waldbieser David A Mcdtl Jeiiery S Terhune ivrark R Liles Abstract Background The bacterial pathogen Edwardsiella ictaluri is d primary cause of mortality in channel catfish raised commercially in aquaculture farms. Additional treatment and diagnostic regimes are needed for this enteric pathogen motivating the discovery and characterization of bacteriophages specific to E. ictaluri. Results The genomes of three Edwardsiella ictaluri-specific bacteriophages isolated from geographically distant aquaculture ponds at different times were sequenced and analyzed. The genomes for phages eiAU eiDWF and eiMSLS are 42.80 kbp 42.12 kbp and 42.69 kbp respectively and are greater than 95 identical to each other at the nucleotide level. Nucleotide differences were mostly observed in non-coding regions and in structural proteins with significant variability in the sequences of putative tail fiber proteins. The genome organization of these phages exhibit a pattern shared by other Siphoviridae. Conclusions These E. ictaluri-specific phage genomes reveal considerable conservation of genomic architecture and sequence identity even with considerable temporal and spatial divergence in their isolation. Their genomic homogeneity is similarly observed among E. ictaluri bacterial isolates. The genomic analysis of these .