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Báo cáo y học: "Membranous nephropathy in a patient with hereditary angioedema: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Membranous nephropathy in a patient with hereditary angioedema: a case report | Journal of Medical Case Reports BioMed Central Open Access Case report Membranous nephropathy in a patient with hereditary angioedema a case report Sandawana W Majoni and Steven R Smith Address Russells Hall Hospital Renal Unit Dudley Group of Hospitals NHS Trust Dudley West Midlands UK Email SandawanaW Majoni - sandawanaw@aol.com Steven R Smith - rssmith@blueyonder.co.uk Corresponding author Published 13 October 2008 Received 20 February 2008 Journal of Medical Case Reports 2008 2 328 doi l0.ll86 l752-l947-2-328 Accepted 13 October 2008 This article is available from http www.jmedicalcasereports.com content 2 l 328 2008 Majoni and Smith licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Hereditary angioedema is the commonest inherited disorder of the complement system and has been associated with several immune glomerular diseases. A case of nephrotic syndrome and renal impairment due to idiopathic membranous glomerulonephritis in a patient with hereditary angioedema has not been described before. Case presentation We present the first reported case of the association of membranous nephropathy and hereditary angioedema in a 43-year-old male Caucasian patient who presented with acute intestinal angioedema hypertension acute pancreatitis renal impairment and generalised body swelling due to severe nephrotic syndrome. We present the challenges involved in the clinical management of the patient. Conclusion This patient s presentation with severe nephrotic syndrome renal impairment and hypertension required aggressive treatment of the membranous nephropathy given the high risk for progression to end stage renal failure. The contraindication to angiotensin converting enzyme inhibitors and angiotensin II .