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Báo cáo y học: " Early detection of Varicella-Zoster Virus (VZV)-specific T-cells before seroconversion in primary varicella infection: case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early detection of Varicella-Zoster Virus (VZV)-specific T-cells before seroconversion in primary varicella infection: case report | Baiker et al. Virology Journal 2010 7 54 http www.virologyj.eom content 7 1 54 VIROLOGY JOURNAL CASE REPORT Open Access Early detection of Varicella-Zoster Virus VZV -specific T-cells before seroconversion in primary varicella infection case report Armin Baiker 1 Rudolf Haase1 Josef Eberle1 Maria Guadalupe Vizoso Pinto1 Klaus-Ingmar Pfrepper2 A I r D - -f- r I - p 2 I II I t A ỉ z t l A m 13 I_I s r f m II -A m 7 X4 I_I r l I i -f- I- - p l z 1 r T I I k k I I 11 -A I -A J z-i M 1 Andreas Petrich Ludwig Deml Hartmut Campe Hans Nitschko Gundula Jaeger Abstract Here we report the case of a 54-year old immunocompetent German patient with primary varicella whose Varicella-Zoster Virus VZV -specific T-cell responses could be detected early in infection and before the onset of seroconversion. This case demonstrates that the detection of VZV-specific T-cells may under certain circumstances support the diagnosis of a primary varicella infection as for example in cases of atypical or subclinical varicella or in the absence of detectable VZV DNA in plasma. Background Varicella-Zoster virus VZV causes varicella during primary infection and may cause herpes zoster after reactivation from latency. Varicella is typically diagnosed by characteristic clinical signs and usually does not require laboratory testing. Due to the introduction of mass vaccination programmes however the incidence of typical varicella has declined. This decline has led to a reduced experience of physicians in diagnosing varicella. Furthermore an increased incidence of atypical and vaccination breakthrough varicella infections has been described 1-4 . For the early diagnosis of cases with severe or atypical varicella rapid VZV identification techniques are indicated to initiate specific antiviral therapy. Serological markers i.e. VZV-IgM and or VZV-IgG are not appropriate for the laboratory diagnosis of e arly varicella because they are detectable in a time-delayed manner 5 . Therefore the method of choice